Ct and mri may provide more detail of the organs consistency. If confirmation of splenomegaly is necessary because the examination is equivocal, ultrasonography is the test of choice because of its accuracy and low cost. Hepatosplenomegaly is a medical condition in which both the liver and the spleen become enlarged. Tuberculous splenomegaly 1 thought that the term primary tb of the spleen is misleading considered that tuberculosis of the spleen must always be secondary.
Evaluation of splenomegaly is notoriously difficult and embarrassingly easy to miss when present. It is a reservoir for platelets and a site for the proliferation of blymphocytes. Early satiety from gastric displacement occurs with massive splenomegaly. Although several methods of palpation and percussion of the spleen have been described, until recently they have not been validated by noninvasive imaging techniques such as ultrasonography, radionuclide scanning, and computed tomography that offer objective means to assess splenomegaly. Recent trauma in area of spleen associated symptoms asymptomatic causes of initially asymptomatic splenomegaly may include early myelproliferaitve disorders, splenic cyst, mild hereditary spherocytosis and even. In normal individuals or in patients with mild splenomegaly, the spleen generally retains its usual tetrahedral shape and there appears to be a good cor relation between measurements whether by mr, ct or ultrasound 1. Splenomegaly causes of splenomegaly portal hypertension 33% chronic liver disease portalsplenic venous obstruction. Primary tuberculosis of the spleen coined by coley in 1846 1 refers to an enlarged spleen from tuberculosis no or little involvement of other organs 1938englebrethholm changed it to. The spleen is a functionally diverse organ with active roles in immunosurveillance and hematopoiesis. The main modalities used are ultrasound and ct fig. The differential diagnosis of splenomegaly includes. During two evaluations of refugee populations in western uganda in march and july 2015, refugees with splenomegaly on physical examination were offered additional assessment and treatment, including abdominal ultrasonography and laboratory testing. Patients may also experience pain,which may be referred to the left shoulder. Splenomegaly hematology and oncology merck manuals.
One third of newborns and 10% of children may normally have a palpable spleen. Hypersplenism is a secondary process that can arise from splenomegaly of almost any cause see table common causes of splenomegaly. Evidencebased physical diagnosis essential here dermatologic diagnosis cellulitis zoster psoriasis neurologic diagnosis parkinsons disease bells palsy amyotrophic lateral sclerosis musculoskeletal diagnosis cardiologic diagnosis pericarditis mitral valve prolapse ophthalmologic diagnosis diabetic retinopathy psychiatric diagnosis. For the clinical diagnosis of splenomegaly, two criteria have been tested. In case if an enlarged spleen or splenomegaly is suspected imaging studies and blood tests will be done to. Prevalence and clinical significance of splenomegaly in. Evaluation of splenomegaly approach bmj best practice. Splenomegaly and hypersplenism information page patient. Pointofcare ultrasonography improves the diagnosis of. All clinical records including laboratory result and medical imaging. Splenomegaly general presentation the spleen is a hematopoietic organ supporting the megakaryotic, lymphoid, erythroid, myeloid, and reticuloendothelial systems. The purpose of both palpation and percussion of the spleen is to look for splenic enlargement. Increased workload of the spleen can be caused by immunologic stress infection, inflammation, or an autoimmune disorder or by increased rbc removal rbc membrane disorders, hemoglobinopathies. What is splenomegalycausessymptomstreatmentdiagnosis.
Assessment of splenomegaly differential diagnosis of. A combination of tests either palpation or percussion increased the diagnostic accuracy. Sep 17, 2015 this was a prospective trial of diagnostic accuracy. Know the causes, symptoms, and treatment of splenomegaly. Comparing physical examination with sonographic versions of. One third of neonates and one tenth of children may have a normal, palpable spleen. Splenomegaly, hypersplenism, and hereditary disorders with. An enlarged spleen may not be palpable until it is 23 times its normal size. Treatment for splenomegaly treatment for splenomegaly depends on the underlying condition.
However, when the tip of the spleen is felt beyond 2 cm below the left costal margin, it is considered abnormal. Splenomegaly pediatrics clerkship the university of. All reported studies discuss splenomegaly arising from im and the assumption is made that detection of enlargement from other etiologies would not differ on physical examination. Although splenomegaly is almost always present in hypersplenism, many patients with splenomegaly do not have hypersplenism. Physical examination inspection, palpation, percussion, auscultation, vital signs, weight, height 3. Even in palpable splenomegaly, radiological assessment is usually necessary to quantitate the abnormality, as discussed above. Palpation and percussion of the spleen are important techniques for identifying an enlarged. Spleen should be twice the normal size to become palpable. These maneuvers have received more extensive evaluation than other maneuvers. The differential diagnosis for splenomegaly is broad but can be grouped into. The differential diagnosis of splenomegaly is extensive table 1. Diagnosis of splenomegaly diagnosing splenomegaly involves a number of tests, including. A 48 yearold woman with abdominal cramping, vomiting, and no bowel movement for 2 days. Tuberculous splenomegaly with the hypersplenism syndrome.
Splenomegaly is an exception rather than the rule, and the hematologic profile is that of selective absence or reduction in the number of neutrophils, while monocytes, eosinophils, and basophils are either normal or increased. If your institution subscribes to this resource, and you dont have a myaccess profile, please contact your librarys reference desk for information on how to. The spleen is felt in 30% of normal newborns and up to 10% of one year olds. However, it may also refer to an enlarged spleen detected by an imaging test. Describe how the physical examination affects the physicianpatient. Congestion cirrhosis, hepatic fibrosis, portal vein thrombosis, splenic vein thrombosis, longstanding congestive heart failure. Diagnosis is based on either the presence of 5 out of 8 criteria fever, splenomegaly, bicytopenia, hypertriglyceridemia andor hypofibrinogenemia, hemophagocytosis, low or absent nkcell activity, hyperferritinemia, and high levels of soluble interleukin2 receptor, or a molecular diagnosis. Splenomegaly american academy of pediatrics textbook of. A detailed history taking, appropriate clinical examination and relevant. Patients and methods we identified 129 patients through the dnrp, that had been given the icd10 splenomegaly diagnosis code in 199420 at odense university hospital, denmark, excluding. Splenomegaly can be caused due to various medical conditions like some sort of an infection or problems with the liver. Comparing physical examination with sonographic versions of the.
Articles causes of massive tropical splenomegaly in ghana. Tropical splenomegaly massive splenomegaly occurring in people of endemic area for malariakalaazar but no parasite is demonstrable in blood. Population for whom the physical examination of splenomegaly should be sought. A list of disorders producing splenomegaly and hypersplenism is presented in table 2. Pdf purpose our aim was to assess the validity of the icd10 code for. Myeloproliferative disorder proliferation of stem cells chronic myeloid leukemia polycythemia thrombocytosis 2. Causes of massive splenomegaly beyond umbilicus in very large spleen lower splenic pole may extend into pelvis and cross abdominal midline. Jul 08, 2019 splenomegaly in childhood is generally first suspected upon physical examination. Splenomegaly is an enlargement of the spleen resulting from abnormalities of its lymphoid, reticuloendothelial, or vascular components. An increase in the size of the spleen can be caused by several mechanisms. Splenomegaly may be a presenting or dominant feature of certain diseases. If your institution subscribes to this resource, and you dont have a myaccess profile, please contact your librarys reference desk for information on how to gain access to this resource from offcampus. The sensitivity for detection of ultrasounddocumented splenic enlargement is 60 to 70% for palpation and 60 to 80% for percussion.
Signs of splenomegaly may include a palpable left upper quadrant abdominal mass or splenic rub. Pdf splenomegaly diagnostic validity, workup, and underlying. In part this is because the spleen enlarges in the inferior anteromedial direction, sometimes as far as the rlq. The content on the uptodate website is not intended nor recommended as a substitute for medical advice, diagnosis, or treatment. Pdf the detection of an enlarged spleen is important in clinical diagnosis but seems to be subject to considerable inaccuracies. The spleen is a fistsized organ in the upper left side of your abdomen, next to your stomach and behind your left ribs. Diagnosis is based on either the presence of 5 out of 8 criteria fever, splenomegaly, bicytopenia, hypertriglyceridemia andor hypofibrinogenemia, hemophagocytosis, low or absent nkcell activity, hyperferritinemia, and high levels of soluble interleukin2 receptor, or a molecular diagnosis consistent with hlh. If you understand the normal and abnormal characteristics of each organ system, you will recognize the pattern of the syndrome and reach the correct diagnosis. Its causes include a variety of conditions that affect these two organs, including liver disease, hiv, anemia, infections, and. It enlarges towards the right iliac fossa rif always start palpation in the rif and move across towards the right upper quadrant or a massive splenomegaly may be missed. Participants received less than 1 h training for ultrasound diagnosis of splenomegaly. Portal hypertension is an important cause of splenomegaly in most tropical countries. Diagnosis is made using criteria developed by the polycythemia vera study group.
However, little is known about the prevalence and clinical significance of this finding in asymptomatic patients. The spleen can be enlarged in up to 30% of newborns and 10% of children. It may be difficult to palpate an enlarged spleen in the settings of obesity, a muscular abdominal wall, or the inability to sufficiently relax the abdominal musculature. Brucellosis schistosomiasis stool ova and parasite s. Jan 22, 2019 splenomegaly is a pathological condition in which spleen of an individual gets enlarged. Reasons for feeling a normal spleen include an unusual position and being pushed down by hyperexpanded lungs.
An enlarged spleen is usually detected during a physical exam. There are different medical conditions that can lead to the simultaneous appearance of hepatomegaly and splenomegaly, as you will have the opportunity to discover below. Because the physical examination is quite insensitive for detecting splenomegaly between 27 and 58 percent, depending on the examiners index of suspicion, the absence of splenomegaly should not be used as evidence against the diagnosis of infectious mononucleosis. To determine whether sonographic versions of physical examination techniques can accurately identify splenomegaly, castells method ann intern med 1967.
The evaluation of splenomegaly in children and considerations related to elective or traumatic splenectomy are discussed separately. Spleen problems and spleen removal some people are born without a spleen or need to have it removed because of illness or injury. Clinical examination for splenomegaly is of questionable value even in the hands of experienced providers. These maneuvers have received more extensive evaluation than other maneuvers, allowing us greater confidence in the findings. Does this patient have intestinal obstruction blockage of intestine. It is important to understand that this condition can lead to a serious or lifethreatening symptoms, if proper medical treatment.
Your spleen is a fistsized organ located behind your stomach and just under your left rib cage. In cases in which splenomegaly is questioned, the clinical examination is more specific than sensitive and is best used when ruling in the diagnosis among patients for whom the suspicion is at least 10%. Always seek the advice of your own physician or other qualified health care professional regarding any medical questions or conditions. Moreover, the examination should start with traube space percussion, followed, if dull, by supine 1handed palpation. Jan 09, 2018 a multicentre observational study for early diagnosis of gaucher disease in patients with splenomegaly andor thrombocytopenia. In the past, splenomegaly was a clinical finding, but in recent years, imaging studies have also helped to assess for or confirm mild splenomegaly. Mri is especially useful in detecting portal or splenic vein thromboses. Also, a palpable left upper quadrant mass may indicate a problem other than an enlarged spleen. A small percentage of the normal american population may have a palpable or enlarged spleen.
Clinical approach to isolated splenomegaly association physicians. Pointofcare ultrasonography improves the diagnosis of splenomegaly in hospitalized patients. Pointofcare ultrasonography improves the diagnosis of splenomegaly in hospitalized patients article pdf available in critical ultrasound journal 71. Splenomegaly is a frequent finding among hivinfected adults 1, 2. Other causes of splenomegaly include infections, liver disease and some cancers.
Splenomegaly increases the spleen s mechanical filtering and destruction of red blood cells rbcs and often of white blood cells wbcs and platelets. Up to 3% of normal, thin, people have a palpable spleen. Splenomegaly is most often discovered under physical examination. Physical diagnosis of the abdomen university of virginia. The use of manual therapy or therapeutic touch has generated extensive literature. Anatomy develops from condensations of mesoderm in the dorsal mesogastrium. A normalsized spleen cannot be palpated felt during the physical examination of the abdomen, except in slender people. Olson ap, trappey b, wagner m, newman m, nixon lj, schnobrich d.
When considering whether an luq mass is an enlarged spleen, features of an enlarged spleen include that. Physical and sonographic examinations for splenomegaly were performed by students, residents and attending physicians enrolled in an ultrasound training course. Although studies on hypersplenism are few, two studies have shown that schistosomal portal hypertension is the commonest cause of hypersplenism, other common causes include hematological disorders, and visceral lesihmaniasis. Get a printable copy pdf file of the complete article 1. In this study there was high interobserver variability, which did not appear to be associated to the level of experience. Enlarged spleen splenomegaly diagnosis and treatment. Splenomegaly increases the spleens mechanical filtering and destruction of red blood cells rbcs and often of white blood cells wbcs and platelets. The algorithms herein attempt to present a rational, stepbystep diagnostic. Splenic palpation for the evaluation of morbidity due to. However, a variety of disorders can cause the spleen to enlarge, sometimes to 2kg or more.
Examiner dependence on physical diagnostic tests for the. Physical diagnostic techniques for the detection of splenomegaly are relatively insensitive but specific. Although splenomegaly is often considered to be an ominous clinical finding, certain normal variants have been found. In an age when ever more refined laboratory tests are the keynote, it may seem anachronistic to describe again a simple method in bedside diagnosis. Enlarged spleen splenomegaly may be easier to palpate during careful abdominal examination. It has been found in up to 70% in a postmortem study. Hypersplenism is a syndrome characterized by splenomegaly and any or all of the following cytopenias. Spleen exam stanford medicine 25 stanford medicine. However, in some people especially those who are slender a healthy, normalsized spleen can sometimes be felt during an exam. The spleen is enlarged in a number of important clinical diagnoses. Generally it is less than 1 cm below the left costal margin. Imaging also delineates the architecture of the enlarged spleen, and distin.
Hepatosplenomegaly refers to an enlargement of the liver and spleen. Assessing for the presence of splenomegaly is an important component of the physical examination. Each patient was examined for splenomegaly using conventional. In children, as a result of the thinness of the abdominal musculature, a palpable spleen is commonly encountered. The term splenomegaly generally denotes a palpably enlarged spleen. The diagnosis of the cause requires a complete history and thorough physical examination with the following points of importance. The physical examination for splenomegaly had a sensitivity of 40 % 95 % ci 1277 % and specificity of 88 % 95 % ci 7495 % while physical examination plus pocus had a sensitivity of 100 % 95 % ci 57100 % and specificity of 74 % 95 % ci 5785 %. Your doctor can often feel it by gently examining your left upper abdomen. Any conditions that cause a rapid breakdown of blood cells, such as any of the haemolytic anaemias, can place great strain on the spleen and make it enlarge. It may also be felt in 1% of normal older children and adolescents. Since the spleen enlarges in many conditions, a systematic approach may facilitate timely and costeffective diagnosis of the cause of splenomegaly.
Pdf pointofcare ultrasonography improves the diagnosis of. This topic provides an overview of normal splenic size and function and an approach to evaluating splenic abnormalities in adults. To determine whether sonographic versions of physical examination. Splenomegaly can be found in 3% of the normal population. It can be detected on physical examination by using castells sign, traubes space percussion or nixons sign, but an ultrasound can be used to confirm diagnosis. On the other hand, as the spleen progressively and. Hepatosplenomegaly hpm is a disorder where both the liver and spleen swell beyond their normal size, due to one of a number of causes. Pdf reliability of clinical techniques for detecting splenic. In patients where the likelihood of splenomegaly is high, the physical exam is not sufficiently sensitive to detect it. The classic causes of massive tropical splenomegaly are hyperreactive malarial splenomegaly formerly tropical splenomegaly syndrome1, schistosomiasis, visceral leishmaniasis, thalassaemia major, chronic myeloid leukaemia, myelofibrosis, and miscellaneous disorders such as splenic cysts, tumours, and lipid storage diseases. Splenomegaly is defined as enlargement of the spleen, measured by size or weight. Pdf hypersplenism is a condition in which the spleen becomes increasingly active and then rapidly removes the blood cells.
Implicit in the definition is that the cytopenias will correct after splenectomy. Igm antibodies against malaria are detected in blood. Conclusion our findings show that the splenomegaly diagnosis in the dnrp is. Most often, the etiology is evident in light of historical and genealogical information and the concurrent presence of familiar, often pathognomonic, physical or laboratory findings e. The most common complaint in patients with splenomegaly is mild, vague, abdominal discomfort. Cause of splenomegaly is obscurelymphocytic infiltration of splenic liver sinosoids present.